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1 Examples of autosomal dominant adult-onset diseases affecting the central nervous system for which genes have been cloned Disease Familial alzheimer disease Familial amyotrophic lateral sclerosis ALS1 ALS susceptibility Familial Parkinson disease PARK1 lewy body PARK4 Frontotemporal dementia with Parkinsonism Creutzfeldt-Jakob disease (CJD) Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy(CADASIL) Familial British dementia (FBD) Gene amyloid precursor gene (APP) APOE4 association Presenilin-1 gene (PSEN 1) Presenilin-2 gene (PSEN 2) superoxide dismutase-1 gene (SOD1) heavy neurofilament subunit gene (NEFH) alpha-synuclein gene (SNCA) microtubule-associated protein tau gene (MAPT) prion protein gene (PRNP) NOTCH 3 ITM2B AD1 AD2 AD3 AD4 Box 10.
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(B) These images show representative 2DE gels loaded with either untreated CSF, fraction bound by depletion columns, or immunodepleted fraction (eluate).
Chapter 1 Introduction 5 Associated Gets glIsEnabled with argument GL_VERTEX_ARRAY glGet with argument GL_VERTEX_ARRAY_SIZE glGet with argument GL_VERTEX_ARRAY_TYPE glGet with argument GL_VERTEX_ARRAY_STRIDE glGet with argument GL_VERTEX_ARRAY_BUFFER_BINDING glGet with argument GL_ARRAY_BUFFER_BINDING glGetPointerv with argument GL_VERTEX_ARRAY_POINTER See Also glArrayElement, 200,000 to 3,000,000 Da (Sudesh, Abe et al.
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 Method Intracellular Recording Extracellular Recording Local Field Potential Recording Field (Surface) Potential Recording Temporal resolution Excellent (direct measure of Vm Excellent (spikes resolved; signal is a derivative of Vm) Moderate (spikes not resolved) Moderate Neqbridge not resolved) Spatial resolution Excellent Very Good Moderate 1 mm3 Poor (resolve voxels of a few mm3) Number of units Very Limited (1 unit) Limited ( 13 units) Moderate (100s1000s of units) Many (e.
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